Relevance of In Vitro Metabolism Models to PET Radiotracer Development: Prediction of In Vivo Clearance in Rats from Microsomal Stability Data

The prediction of in vivo clearance from in vitro metabolism models such as liver microsomes is an established procedure in drug discovery. The potentials and limitations of this approach have been extensively evaluated in the pharmaceutical sector; however, this is not the case for the field of pos...

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Detalles Bibliográficos
Autores principales: Schneider, Daniela, Oskamp, Angela, Holschbach, Marcus, Neumaier, Bernd, Bauer, Andreas, Bier, Dirk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6631687/
https://www.ncbi.nlm.nih.gov/pubmed/31013984
http://dx.doi.org/10.3390/ph12020057

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6631687/
https://www.ncbi.nlm.nih.gov/pubmed/31013984
http://dx.doi.org/10.3390/ph12020057

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