Paclitaxel-Loaded Silk Fibroin Nanoparticles: Method Validation by UHPLC-MS/MS to Assess an Exogenous Approach to Load Cytotoxic Drugs

The aim of this work was to load an anticancer drug, paclitaxel (PTX), on Silk Fibroin Nanoparticles (SFNs) by using an exogenous approach. SFNs were produced, freeze-dried and then loaded with PTX. An exogenous method allowed us to reduce both drug loss and environmental impact. In order to quantif...

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Detalles Bibliográficos
Autores principales: Perteghella, Sara, Sottani, Cristina, Coccè, Valentina, Negri, Sara, Cavicchini, Loredana, Alessandri, Giulio, Cottica, Danilo, Torre, Maria Luisa, Grignani, Elena, Pessina, Augusto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6631745/
https://www.ncbi.nlm.nih.gov/pubmed/31213025
http://dx.doi.org/10.3390/pharmaceutics11060285

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6631745/
https://www.ncbi.nlm.nih.gov/pubmed/31213025
http://dx.doi.org/10.3390/pharmaceutics11060285

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