Evaluation of In-Batch and In-Flow Synthetic Strategies towards the Stereoselective Synthesis of a Fluorinated Analogue of Retro-Thiorphan

A stereoselective synthetic strategy for the preparation of trifluoromethylamine mimics of retro-thiorphan, involving a diastereoselective, metal-free catalytic step, has been studied in batch and afforded the target molecule in good yields and high diastereoselectivity. A crucial point of the synth...

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Detalles Bibliográficos
Autores principales: Pirola, Margherita, Puglisi, Alessandra, Raimondi, Laura, Forni, Alessandra, Benaglia, Maurizio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6631789/
https://www.ncbi.nlm.nih.gov/pubmed/31216628
http://dx.doi.org/10.3390/molecules24122260

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6631789/
https://www.ncbi.nlm.nih.gov/pubmed/31216628
http://dx.doi.org/10.3390/molecules24122260

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