Cargando…
Identification of Marek’s Disease Virus VP22 Tegument Protein Domains Essential for Virus Cell-to-Cell Spread, Nuclear Localization, Histone Association and Cell-Cycle Arrest
VP22 is a major tegument protein of alphaherpesviruses encoded by the UL49 gene. Two properties of VP22 were discovered by studying Marek’s disease virus (MDV), the Mardivirus prototype; it has a major role in virus cell-to-cell spread and in cell cycle modulation. This 249 AA-long protein contains...
Autores principales: | Trapp-Fragnet, Laëtitia, Courvoisier, Katia, Rémy, Sylvie, Le Pape, G., Loustalot, Fabien, Denesvre, Caroline |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6631903/ https://www.ncbi.nlm.nih.gov/pubmed/31181775 http://dx.doi.org/10.3390/v11060537 |
Ejemplares similares
-
Cell Cycle Modulation by Marek’s Disease Virus: The Tegument Protein VP22 Triggers S-Phase Arrest and DNA Damage in Proliferating Cells
por: Trapp-Fragnet, Laëtitia, et al.
Publicado: (2014) -
Keratinocytes derived from chicken embryonic stem cells support Marek’s disease virus infection: a highly differentiated cell model to study viral replication and morphogenesis
por: Couteaudier, Mathilde, et al.
Publicado: (2016) -
Marek’s disease virus prolongs survival of primary chicken B-cells by inducing a senescence-like phenotype
por: Trapp-Fragnet, Laëtitia, et al.
Publicado: (2021) -
Atrophy of primary lymphoid organs induced by Marek’s disease virus during early infection is associated with increased apoptosis, inhibition of cell proliferation and a severe B-lymphopenia
por: Berthault, Camille, et al.
Publicado: (2018) -
The sulphated polysaccharides extract ulvans from Ulva armoricana limits Marek’s disease virus dissemination in vitro and promotes viral reactivation in lymphoid cells
por: Bussy, Frédérick, et al.
Publicado: (2022)