Physiologically Relevant In Vitro-In Vivo Correlation (IVIVC) Approach for Sildenafil with Site-Dependent Dissolution

This study aimed to establish a physiologically relevant in vitro-in vivo correlation (IVIVC) model reflecting site-dependent dissolution kinetics for sildenafil based on population-pharmacokinetic (POP-PK) modeling. An immediate release (IR, 20 mg) and three sustained release (SR, 60 mg) sildenafil...

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Detalles Bibliográficos
Autores principales: Kim, Tae Hwan, Shin, Soyoung, Jeong, Seok Won, Lee, Jong Bong, Shin, Beom Soo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6631943/
https://www.ncbi.nlm.nih.gov/pubmed/31159390
http://dx.doi.org/10.3390/pharmaceutics11060251

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6631943/
https://www.ncbi.nlm.nih.gov/pubmed/31159390
http://dx.doi.org/10.3390/pharmaceutics11060251

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