Stable enhancers are active in development, and fragile enhancers are associated with evolutionary adaptation

BACKGROUND: Despite continual progress in the identification and characterization of trait- and disease-associated variants that disrupt transcription factor (TF)-DNA binding, little is known about the distribution of TF binding deactivating mutations (deMs) in enhancer sequences. Here, we focus on...

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Detalles Bibliográficos
Autores principales: Li, Shan, Kvon, Evgeny Z., Visel, Axel, Pennacchio, Len A., Ovcharenko, Ivan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6631995/
https://www.ncbi.nlm.nih.gov/pubmed/31307522
http://dx.doi.org/10.1186/s13059-019-1750-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6631995/
https://www.ncbi.nlm.nih.gov/pubmed/31307522
http://dx.doi.org/10.1186/s13059-019-1750-z

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