Scale-Up Strategy in Quality by Design Approach for Pharmaceutical Blending Process with Discrete Element Method Simulation

An approach combining quality by design (QbD) and the discrete element method (DEM) is proposed to establish an effective scale-up strategy for the blending process of an amlodipine formulation prepared by the direct compression method. Critical process parameters (CPPs) for intermediate critical qu...

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Detalles Bibliográficos
Autores principales: Yeom, Su Bin, Choi, Du Hyung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6632066/
https://www.ncbi.nlm.nih.gov/pubmed/31174362
http://dx.doi.org/10.3390/pharmaceutics11060264

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6632066/
https://www.ncbi.nlm.nih.gov/pubmed/31174362
http://dx.doi.org/10.3390/pharmaceutics11060264

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