Using Single-Molecule Chemo-Mechanical Unfolding to Simultaneously Probe Multiple Structural Parameters in Protein Folding

While single-molecule force spectroscopy has greatly advanced the study of protein folding, there are limitations to what can be learned from studying the effect of force alone. We developed a novel technique, chemo-mechanical unfolding, that combines multiple perturbants—force and chemical denatura...

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Detalles Bibliográficos
Autores principales: Guinn, Emily J., Marqusee, Susan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Protocol
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6632164/
https://www.ncbi.nlm.nih.gov/pubmed/31164612
http://dx.doi.org/10.3390/mps2020032

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6632164/
https://www.ncbi.nlm.nih.gov/pubmed/31164612
http://dx.doi.org/10.3390/mps2020032

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