Human PRPF40B regulates hundreds of alternative splicing targets and represses a hypoxia expression signature

Altered splicing contributes to the pathogenesis of human blood disorders including myelodysplastic syndromes (MDS) and leukemias. Here we characterize the transcriptomic regulation of PRPF40B, which is a splicing factor mutated in a small fraction of MDS patients. We generated a full PRPF40B knocko...

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Detalles Bibliográficos
Autores principales: Lorenzini, Paolo Alberto, Chew, Resilind Su Ern, Tan, Cheryl Weiqi, Yong, Jing Yen, Zhang, Fan, Zheng, Jie, Roca, Xavier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6633195/
https://www.ncbi.nlm.nih.gov/pubmed/31088860
http://dx.doi.org/10.1261/rna.069534.118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6633195/
https://www.ncbi.nlm.nih.gov/pubmed/31088860
http://dx.doi.org/10.1261/rna.069534.118

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