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A highly ordered, nonprotective MALAT1 ENE structure is adopted prior to triplex formation
The 3′ end of the ∼7 kb lncRNA MALAT1 contains an evolutionarily and structurally conserved element for nuclear expression (ENE) which confers protection from cellular degradation pathways. Formation of an ENE triple helix is required to support transcript accumulation, leading to persistent oncogen...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Cold Spring Harbor Laboratory Press
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6633196/ https://www.ncbi.nlm.nih.gov/pubmed/31113838 http://dx.doi.org/10.1261/rna.069906.118 |