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Phenotype of ribonuclease 1 deficiency in mice

Biological roles for extracellular RNA (eRNA) have become apparent. For example, eRNA can induce contact activation in blood via activation of the plasma proteases factor XII (FXII) and factor XI (FXI). We sought to reveal the biological role of the secretory enzyme ribonuclease 1 (RNase 1) in an or...

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Detalles Bibliográficos
Autores principales: Garnett, Emily R., Lomax, Jo E., Mohammed, Bassem M., Gailani, David, Sheehan, John P., Raines, Ronald T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6633200/
https://www.ncbi.nlm.nih.gov/pubmed/31053653
http://dx.doi.org/10.1261/rna.070433.119