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Rho kinase-dependent apical constriction counteracts M-phase apical expansion to enable mouse neural tube closure

Cellular generation of mechanical forces required to close the presumptive spinal neural tube, the ‘posterior neuropore’ (PNP), involves interkinetic nuclear migration (INM) and apical constriction. Both processes change the apical surface area of neuroepithelial cells, but how they are biomechanica...

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Detalles Bibliográficos
Autores principales: Butler, Max B., Short, Nina E., Maniou, Eirini, Alexandre, Paula, Greene, Nicholas D. E., Copp, Andrew J., Galea, Gabriel L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6633395/
https://www.ncbi.nlm.nih.gov/pubmed/31182644
http://dx.doi.org/10.1242/jcs.230300