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A trap mutant reveals the physiological client spectrum of TRC40

The transmembrane recognition complex (TRC) pathway targets tail-anchored (TA) proteins to the membrane of the endoplasmic reticulum (ER). While many TA proteins are known to be able to use this pathway, it is essential for the targeting of only a few. Here, we uncover a large number of TA proteins...

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Detalles Bibliográficos
Autores principales: Coy-Vergara, Javier, Rivera-Monroy, Jhon, Urlaub, Henning, Lenz, Christof, Schwappach, Blanche
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6633398/
https://www.ncbi.nlm.nih.gov/pubmed/31182645
http://dx.doi.org/10.1242/jcs.230094