Desumoylation of aggrecan and collagen II facilitates degradation via aggrecanases in IL-1β-mediated osteoarthritis

Background: Aggrecan plays a crucial role in the ability of tissues to withstand compressive loads during the pathological progression of osteoarthritis (OA). Progressive loss of aggrecan from cartilage may result in exposure of the collagen matrix and can lead to its disintegration by metalloprotea...

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Detalles Bibliográficos
Autores principales: Zhu, Bing, Cui, Guanxing, Zhang, Qifu, Cheng, Xiankui, Tang, Shusen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2019
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6634300/
https://www.ncbi.nlm.nih.gov/pubmed/31372032
http://dx.doi.org/10.2147/JPR.S194306

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6634300/
https://www.ncbi.nlm.nih.gov/pubmed/31372032
http://dx.doi.org/10.2147/JPR.S194306

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