Cargando…

Desumoylation of aggrecan and collagen II facilitates degradation via aggrecanases in IL-1β-mediated osteoarthritis

Background: Aggrecan plays a crucial role in the ability of tissues to withstand compressive loads during the pathological progression of osteoarthritis (OA). Progressive loss of aggrecan from cartilage may result in exposure of the collagen matrix and can lead to its disintegration by metalloprotea...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhu, Bing, Cui, Guanxing, Zhang, Qifu, Cheng, Xiankui, Tang, Shusen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2019
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6634300/ https://www.ncbi.nlm.nih.gov/pubmed/31372032 http://dx.doi.org/10.2147/JPR.S194306

Ejemplares similares

Roles of metalloproteinase-3 and aggrecanase 1 and 2 in aggrecan cleavage during human meniscus degeneration
por: Ishihara, Gintaro, et al.
Publicado: (2009)

Extracellular Matrix Proteomics Reveals Interplay of Aggrecan and Aggrecanases in Vascular Remodeling of Stented Coronary Arteries
por: Suna, Gonca, et al.
Publicado: (2018)

Development of a highly sensitive chemiluminescence immunoassay for quantification of aggrecanase-generated ARGS aggrecan fragments in serum
por: He, Yi, et al.
Publicado: (2021)

Aggrecanases and cartilage matrix degradation
por: Nagase, Hideaki, et al.
Publicado: (2003)

Blood and urine biomarkers in osteoarthritis – an update on cartilage associated type II collagen and aggrecan markers
por: Bay-Jensen, Anne C., et al.
Publicado: (2022)

Suppression of MMP activity in bovine cartilage explants cultures has little if any effect on the release of aggrecanase-derived aggrecan fragments
por: Wang, Bijue, et al.
Publicado: (2009)

Tumor necrosis factor alpha-dependent aggrecan cleavage and release of glycosaminoglycans in the meniscus is mediated by nitrous oxide-independent aggrecanase activity in vitro
por: Voigt, Henning, et al.
Publicado: (2009)

Genetic variation of aggrecanase-2 (ADAMTS5) in susceptibility to osteoarthritis
por: Zhou, Xindie, et al.
Publicado: (2019)

Effect of Resveratrol on Serum Levels of Type II Collagen and Aggrecan in Patients with Knee Osteoarthritis: A Pilot Clinical Study
por: Marouf, Bushra Hassan
Publicado: (2021)

Targeting Aggrecanases for Osteoarthritis Therapy: From Zinc Chelation to Exosite Inhibition
por: Cuffaro, Doretta, et al.
Publicado: (2022)

Cartilage degradation is fully reversible in the presence of aggrecanase but not matrix metalloproteinase activity
por: Karsdal, Morten A, et al.
Publicado: (2008)

Aggrecan heterogeneity in articular cartilage from patients with osteoarthritis
por: Mort, John S., et al.
Publicado: (2016)

CXCL12/CXCR4 Axis Regulates Aggrecanase Activation and Cartilage Degradation in a Post-Traumatic Osteoarthritis Rat Model
por: Lu, Weiwei, et al.
Publicado: (2016)

High molecular weight hyaluronan protects cartilage from degradation by inhibiting aggrecanase expression
por: Ohtsuki, Takashi, et al.
Publicado: (2018)

Matrilin-3 Induction of IL-1 receptor antagonist Is required for up-regulating collagen II and aggrecan and down-regulating ADAMTS-5 gene expression
por: Jayasuriya, Chathuraka T, et al.
Publicado: (2012)

IL-1β promotes ADAMTS enzyme-mediated aggrecan degradation through NF-κB in human intervertebral disc
por: Sun, Zhongyi, et al.
Publicado: (2015)

Activation of GPR40 Suppresses AGE-Induced Reduction of Type II Collagen and Aggrecan in Human SW1353 Chondrocytes
por: Gu, Jiaxiang, et al.
Publicado: (2020)

The JAK/STAT pathway but not the Erk1/2 pathway mediates IL-6/sIL-6R downregulation of type II collagen, aggrecan core and link protein transcription in articular chondrocytes
por: Bogdanowicz, P, et al.
Publicado: (2003)

Metalloelastase-12 is involved in the temporomandibular joint inflammatory response as well as cartilage degradation by aggrecanases in STR/Ort mice
por: Yamashita-Futani, Yoko, et al.
Publicado: (2021)

The role of synovial macrophages and macrophage-produced cytokines in driving aggrecanases, matrix metalloproteinases, and other destructive and inflammatory responses in osteoarthritis
por: Bondeson, Jan, et al.
Publicado: (2006)

SENP3-mediated deSUMOylation of Drp1 facilitates interaction with Mff to promote cell death
por: Guo, Chun, et al.
Publicado: (2017)

Activation of β-catenin signaling in aggrecan-expressing cells in temporomandibular joint causes osteoarthritis-like defects
por: Hui, Tianqian, et al.
Publicado: (2018)

Antibody-based exosite inhibitors of ADAMTS-5 (aggrecanase-2)
por: Santamaria, Salvatore, et al.
Publicado: (2015)

Bone morphogenic protein (BMP-2) enhances expression of type II collagen and aggrecan in human chondrocytes in 3D alginate cultures
por: Aicher, WK, et al.
Publicado: (2004)

Aggrecanase-selective tissue inhibitor of metalloproteinase-3 (TIMP3) protects articular cartilage in a surgical mouse model of osteoarthritis
por: Nakamura, Hiroyuki, et al.
Publicado: (2020)

TIMP-3 inhibits aggrecan breakdown in pig articular cartilage stimulated with IL-1
por: Nagase, H, et al.
Publicado: (2003)

Association between synovial fluid levels of aggrecan ARGS fragments and radiographic progression in knee osteoarthritis
por: Larsson, Staffan, et al.
Publicado: (2010)

Aggrecan Hypomorphism Compromises Articular Cartilage Biomechanical Properties and Is Associated with Increased Incidence of Spontaneous Osteoarthritis
por: Alberton, Paolo, et al.
Publicado: (2019)

DeSUMOylation of a Verticillium dahliae enolase facilitates virulence by derepressing the expression of the effector VdSCP8
por: Wu, Xue-Ming, et al.
Publicado: (2023)

The role of aggrecan in normal and osteoarthritic cartilage
por: Roughley, Peter J, et al.
Publicado: (2014)

Control of progesterone receptor transcriptional synergy by SUMOylation and deSUMOylation
por: Abdel-Hafiz, Hany A, et al.
Publicado: (2012)

DeSUMOylation Controls Insulin Exocytosis in Response to Metabolic Signals
por: Vergari, Elisa, et al.
Publicado: (2012)

Evidence for lysosomal exocytosis and release of aggrecan-degrading hydrolases from hypertrophic chondrocytes, in vitro and in vivo
por: Bastow, Edward R., et al.
Publicado: (2012)

Hyaluronan inhibits expression of ADAMTS4 (aggrecanase-1) in human osteoarthritic chondrocytes
por: Yatabe, T, et al.
Publicado: (2009)

Collagenases and aggrecanases: understanding the role of non-catalytic domains in cartilage matrix breakdown
por: Nagase, H, et al.
Publicado: (2005)

Microvesicles shed by oligodendroglioma cells and rheumatoid synovial fibroblasts contain aggrecanase activity
por: Lo Cicero, Alessandra, et al.
Publicado: (2012)

Gonadal steroids regulate the expression of aggrecanases in human endometrial stromal cells in vitro
por: Wen, Jiadi, et al.
Publicado: (2013)

Borrelia burgdorferi aggrecanase activity: more evidence for persistent infection in Lyme disease
por: Stricker, Raphael B., et al.
Publicado: (2013)

SENP3-mediated deSUMOylation of c-Jun facilitates microglia-induced neuroinflammation after cerebral ischemia and reperfusion injury
por: Xia, Qian, et al.
Publicado: (2023)

A systematic review of the relationship between the distributions of aggrecan gene VNTR polymorphism and degenerative disc disease/osteoarthritis
por: Cong, L., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_ekld2bpbldkje15qs11pdjf5vp