Oncogenic KIT mutations induce STAT3-dependent autophagy to support cell proliferation in acute myeloid leukemia

Autophagy is associated with both survival and cell death in myeloid malignancies. Therefore, deciphering its role in different genetically defined subtypes of acute myeloid leukemia (AML) is critical. Activating mutations of the KIT receptor tyrosine kinase are frequently detected in core-binding f...

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Detalles Bibliográficos
Autores principales: Larrue, Clément, Heydt, Quentin, Saland, Estelle, Boutzen, Héléna, Kaoma, Tony, Sarry, Jean-Emmanuel, Joffre, Carine, Récher, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6635375/
https://www.ncbi.nlm.nih.gov/pubmed/31311917
http://dx.doi.org/10.1038/s41389-019-0148-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6635375/
https://www.ncbi.nlm.nih.gov/pubmed/31311917
http://dx.doi.org/10.1038/s41389-019-0148-9

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