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Defining a Spinal Microcircuit that Gates Myelinated Afferent Input: Implications for Tactile Allodynia

Chronic pain presents a major unmet clinical problem. The development of more effective treatments is hindered by our limited understanding of the neuronal circuits underlying sensory perception. Here, we show that parvalbumin (PV)-expressing dorsal horn interneurons modulate the passage of sensory...

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Detalles Bibliográficos
Autores principales: Boyle, Kieran A., Gradwell, Mark A., Yasaka, Toshiharu, Dickie, Allen C., Polgár, Erika, Ganley, Robert P., Orr, Desmond P.H., Watanabe, Masahiko, Abraira, Victoria E., Kuehn, Emily D., Zimmerman, Amanda L., Ginty, David D., Callister, Robert J., Graham, Brett A., Hughes, David I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6635381/
https://www.ncbi.nlm.nih.gov/pubmed/31291586
http://dx.doi.org/10.1016/j.celrep.2019.06.040