Mechanism of catalysis and inhibition of Mycobacterium tuberculosis SapM, implications for the development of novel antivirulence drugs

Mycobacterium tuberculosis (Mtb) SapM is a secreted virulence factor critical for intracellular survival of the pathogen. The role of SapM in phagosome maturation arrest in host macrophages suggests its potential as a drug target to assist in the clearance of tuberculosis infection. However, the mec...

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Detalles Bibliográficos
Autores principales: Fernandez-Soto, Paulina, Bruce, Alexander J. E., Fielding, Alistair J., Cavet, Jennifer S., Tabernero, Lydia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6635428/
https://www.ncbi.nlm.nih.gov/pubmed/31312014
http://dx.doi.org/10.1038/s41598-019-46731-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6635428/
https://www.ncbi.nlm.nih.gov/pubmed/31312014
http://dx.doi.org/10.1038/s41598-019-46731-6

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