Cargando…

Bromodomain inhibitor JQ1 reversibly blocks IFN-γ production

As a class, ‘BET’ inhibitors disrupt binding of bromodomain and extra-terminal motif (BET) proteins, BRD2, BRD3, BRD4 and BRDT, to acetylated histones preventing recruitment of RNA polymerase 2 to enhancers and promoters, especially super-enhancers, to inhibit gene transcription. As such, BET inhibi...

Descripción completa

Detalles Bibliográficos
Autores principales: Gibbons, Hunter R., Mi, Deborah J., Farley, Virginia M., Esmond, Tashawna, Kaood, Mary B., Aune, Thomas M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6635431/
https://www.ncbi.nlm.nih.gov/pubmed/31311960
http://dx.doi.org/10.1038/s41598-019-46516-x