STAT1 Gain-of-Function Mutations Cause High Total STAT1 Levels With Normal Dephosphorylation

Signal transducer and activator of transcription (STAT1)1 gain of function (GOF) pathogenic variants have been associated with increased levels of phosphorylated STAT1 and STAT1-dependent cellular responses. Delayed dephosphorylation was proposed as the underlying mechanism leading to the characteri...

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Detalles Bibliográficos
Autores principales: Zimmerman, Ofer, Olbrich, Peter, Freeman, Alexandra F., Rosen, Lindsey B., Uzel, Gulbu, Zerbe, Christa S., Rosenzweig, Sergio D., Kuehn, Hye Sun, Holmes, Kevin L., Stephany, David, Ding, Li, Sampaio, Elizabeth P., Hsu, Amy P., Holland, Steven M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6635460/
https://www.ncbi.nlm.nih.gov/pubmed/31354696
http://dx.doi.org/10.3389/fimmu.2019.01433

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6635460/
https://www.ncbi.nlm.nih.gov/pubmed/31354696
http://dx.doi.org/10.3389/fimmu.2019.01433

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