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The Impact of Carboxylesterases in Drug Metabolism and Pharmacokinetics
Background: Carboxylesterases (CES) play a critical role in catalyzing hydrolysis of esters, amides, carbamates and thioesters, as well as bioconverting prodrugs and soft drugs. The unique tissue distribution of CES enzymes provides great opportunities to design prodrugs or soft drugs for tissue tar...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Bentham Science Publishers
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6635651/ https://www.ncbi.nlm.nih.gov/pubmed/30129408 http://dx.doi.org/10.2174/1389200219666180821094502 |