Dimeric FcγR ectodomains detect pathogenic anti‐platelet factor 4–heparin antibodies in heparin‐induced thromobocytopenia

ESSENTIALS: FcγRIIa mediates life‐threatening heparin‐induced thrombocytopenia (HIT). Most anti‐platelet factor (PF)4‐heparin IgGs are not pathogenic so diagnosis of HIT is challenging. Dimeric rsFcγRIIa was used to quantify receptor‐binding activity of anti‐PF4‐heparin antibodies. Dimeric rsFcγRIIa...

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Detalles Bibliográficos
Autores principales: Wines, B. D., Tan, C. W., Duncan, E., McRae, S., Baker, R. I., Andrews, R. K., Esparon, S., Gardiner, E. E., Hogarth, P. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
PLATELETS
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6635755/
https://www.ncbi.nlm.nih.gov/pubmed/30269432
http://dx.doi.org/10.1111/jth.14306

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6635755/
https://www.ncbi.nlm.nih.gov/pubmed/30269432
http://dx.doi.org/10.1111/jth.14306

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