Cargando…

Dimeric FcγR ectodomains detect pathogenic anti‐platelet factor 4–heparin antibodies in heparin‐induced thromobocytopenia

ESSENTIALS: FcγRIIa mediates life‐threatening heparin‐induced thrombocytopenia (HIT). Most anti‐platelet factor (PF)4‐heparin IgGs are not pathogenic so diagnosis of HIT is challenging. Dimeric rsFcγRIIa was used to quantify receptor‐binding activity of anti‐PF4‐heparin antibodies. Dimeric rsFcγRIIa...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wines, B. D., Tan, C. W., Duncan, E., McRae, S., Baker, R. I., Andrews, R. K., Esparon, S., Gardiner, E. E., Hogarth, P. M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2018
Materias:	PLATELETS
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6635755/ https://www.ncbi.nlm.nih.gov/pubmed/30269432 http://dx.doi.org/10.1111/jth.14306

Ejemplares similares

Genome-wide association study of platelet factor 4/heparin antibodies in heparin-induced thrombocytopenia
por: Giles, Jason B., et al.
Publicado: (2022)

Measurement of procoagulant platelets provides mechanistic insight and diagnostic potential in heparin‐induced thrombocytopenia
por: Lee, Christine S. M., et al.
Publicado: (2022)

Clustering of glycoprotein VI (GPVI) dimers upon adhesion to collagen as a mechanism to regulate GPVI signaling in platelets
por: Poulter, N. S., et al.
Publicado: (2017)

Combination of two complementary automated rapid assays for diagnosis of heparin‐induced thrombocytopenia (HIT)
por: Warkentin, Theodore E., et al.
Publicado: (2020)

Combinations of rapid immunoassays for a speedy diagnosis of heparin‐induced thrombocytopenia
por: Rittener‐Ruff, Luana, et al.
Publicado: (2022)

Temporal presentations of heparin‐induced thrombocytopenia following cardiac surgery: A single‐center, retrospective cohort study
por: Warkentin, Theodore E., et al.
Publicado: (2022)

Heparin or nonheparin anticoagulants for VITT
por: Arnold, Donald M.
Publicado: (2022)

Platelet collagen receptor Glycoprotein VI‐dimer recognizes fibrinogen and fibrin through their D‐domains, contributing to platelet adhesion and activation during thrombus formation
por: Induruwa, I., et al.
Publicado: (2018)

Altered Fc glycosylation of anti‐HLA alloantibodies in hemato‐oncological patients receiving platelet transfusions
por: van Osch, Thijs L. J., et al.
Publicado: (2022)

Non-genomic effects of PPARγ ligands: inhibition of GPVI-stimulated platelet activation
por: Moraes, L A, et al.
Publicado: (2010)

Platelet FcγRIIA-induced serotonin release exacerbates the severity of transfusion-related acute lung injury in mice
por: El Mdawar, Marie-Belle, et al.
Publicado: (2021)

Managing argatroban in heparin‐induced thrombocytopenia: A retrospective analysis of 729 treatment days in 32 patients with confirmed heparin‐induced thrombocytopenia
por: Marchetti, Matteo, et al.
Publicado: (2022)

Fc Binding by FcγRIIa Is Essential for Cellular Activation by the Anti-FcγRIIa mAbs 8.26 and 8.2
por: Wines, Bruce D., et al.
Publicado: (2021)

Mean platelet size related to glycoprotein-specific autoantibodies and platelet-associated IgG
por: JAVELA, K, et al.
Publicado: (2007)

The platelet-surface thiol isomerase enzyme ERp57 modulates platelet function
por: Holbrook, L-M, et al.
Publicado: (2012)

PPARγ agonists negatively regulate αIIbβ3 integrin outside‐in signaling and platelet function through up‐regulation of protein kinase A activity
por: Unsworth, A. J., et al.
Publicado: (2017)

Prospective multicentre cohort study of heparin-induced thrombocytopenia in acute ischaemic stroke patients
por: Kawano, Hiroyuki, et al.
Publicado: (2011)

Amplification of human platelet activation by surface pannexin-1 channels
por: Taylor, K A, et al.
Publicado: (2014)

Activation mechanism dependent surface exposure of cellular factor XIII on activated platelets and platelet microparticles
por: Somodi, Laura, et al.
Publicado: (2022)

Differential roles for the adapters Gads and LAT in platelet activation by GPVI and CLEC-2
por: HUGHES, C E, et al.
Publicado: (2008)

Anti‐platelet antibodies in childhood immune thrombocytopenia: Prevalence and prognostic implications
por: Schmidt, David E., et al.
Publicado: (2020)

Super‐resolution microscopy as a potential approach to diagnosis of platelet granule disorders
por: Westmoreland, D., et al.
Publicado: (2016)

Platelet count and indices as postpartum hemorrhage risk factors: a retrospective cohort study
por: van Dijk, Wobke E. M., et al.
Publicado: (2021)

SMIFH2 inhibition of platelets demonstrates a critical role for formin proteins in platelet cytoskeletal dynamics
por: Green, Hannah L. H., et al.
Publicado: (2020)

Modified platelet deposition on matrix metalloproteinase 13 digested collagen I
por: Howes, J.‐M., et al.
Publicado: (2015)

Novel assay demonstrates that coronary artery disease patients have heightened procoagulant platelet response
por: Pasalic, L., et al.
Publicado: (2018)

Platelet endothelial cell adhesion molecule-1 regulates collagen-stimulated platelet function by modulating the association of phosphatidylinositol 3-kinase with Grb-2-associated binding protein-1 and linker for activation of T cells
por: Moraes, L A, et al.
Publicado: (2010)

Multimerin 1 supports platelet function in vivo and binds to specific GPAGPOGPX motifs in fibrillar collagens that enhance platelet adhesion
por: Leatherdale, Alexander, et al.
Publicado: (2020)

Manipulating megakaryocytes to manufacture platelets ex vivo
por: Karagiannis, P, et al.
Publicado: (2015)

The chaperone protein HSP47: a platelet collagen binding protein that contributes to thrombosis and hemostasis
por: Sasikumar, P., et al.
Publicado: (2018)

Flow cytometric mepacrine fluorescence can be used for the exclusion of platelet dense granule deficiency
por: van Asten, Ivar, et al.
Publicado: (2019)

Localized endothelial‐based control of platelet aggregation and coagulation under flow: A proof‐of‐principle vessel‐on‐a‐chip study
por: Brouns, Sanne L.N., et al.
Publicado: (2020)

Use of next‐generation sequencing and candidate gene analysis to identify underlying defects in patients with inherited platelet function disorders
por: Leo, V. C., et al.
Publicado: (2015)

Circulating primers enhance platelet function and induce resistance to antiplatelet therapy
por: Blair, T A, et al.
Publicado: (2015)

The formyl peptide fMLF primes platelet activation and augments thrombus formation
por: Salamah, Maryam F., et al.
Publicado: (2019)

Phagocytosis by endothelial cells inhibits procoagulant activity of platelets of essential thrombocythemia in vitro
por: Ji, Shuting, et al.
Publicado: (2019)

Removal of platelets from blood plasma to improve the quality of extracellular vesicle research
por: Bettin, Britta, et al.
Publicado: (2022)

A humanized monoclonal antibody that inhibits platelet‐surface ERp72 reveals a role for ERp72 in thrombosis
por: Holbrook, L.‐M., et al.
Publicado: (2018)

Heparin Induced Thrombocytopenia in Patients with COVID-19
por: Warrior, Surbhi, et al.
Publicado: (2020)

Antiprothrombin antibodies induce platelet activation: A possible explanation for anti‐FXa therapy failure in patients with antiphospholipid syndrome?
por: Chayoua, Walid, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_0atfgog744jb0cu2q3g2j39d2b