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Super-enhancers: critical roles and therapeutic targets in hematologic malignancies

Super-enhancers (SEs) in a broad range of human cell types are large clusters of enhancers with aberrant high levels of transcription factor binding, which are central to drive expression of genes in controlling cell identity and stimulating oncogenic transcription. Cancer cells acquire super-enhanc...

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Detalles Bibliográficos
Autores principales: Jia, Yunlu, Chng, Wee-Joo, Zhou, Jianbiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6636097/
https://www.ncbi.nlm.nih.gov/pubmed/31311566
http://dx.doi.org/10.1186/s13045-019-0757-y