Cargando…

Differential Sensitivity to IL-12 Drives Sex-Specific Differences in the CD8+ T Cell Response to Infection

It is well known that males and females respond differently to intracellular pathogens. Females mount a more robust immune response than males, which decreases their susceptibility to infection but comes at the cost of increasing immunopathology. However, the underlying basis for sex-specific differ...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yee Mon, Kristel Joy, Goldsmith, Elizabeth, Watson, Neva B., Wang, Jocelyn, Smith, Norah L., Rudd, Brian D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6636834/ https://www.ncbi.nlm.nih.gov/pubmed/31317126 http://dx.doi.org/10.4049/immunohorizons.1800066

Ejemplares similares

Early microbial exposure shapes adult immunity by altering CD8+ T cell development
por: Tabilas, Cybelle, et al.
Publicado: (2022)

Langerin(+) CD8α(+) Dendritic Cells Drive Early CD8(+) T Cell Activation and IL-12 Production During Systemic Bacterial Infection
por: Prendergast, Kelly A., et al.
Publicado: (2018)

miR-150 Regulates Differentiation and Cytolytic Effector Function in CD8+ T cells
por: Smith, Norah L., et al.
Publicado: (2015)

Modeling the dynamics of neonatal CD8+ T cell responses
por: Reynaldi, Arnold, et al.
Publicado: (2016)

MicroRNAs and Their Targets Are Differentially Regulated in Adult and Neonatal Mouse CD8+ T Cells
por: Wissink, Erin M., et al.
Publicado: (2015)

Loss of DAP12 and FcRγ Drives Exaggerated IL-12 Production and CD8(+) T Cell Response by CCR2(+) Mo-DCs
por: Gmyrek, Grzegorz B., et al.
Publicado: (2013)

IL-12 Signaling Contributes to the Reprogramming of Neonatal CD8(+) T Cells
por: Gutiérrez-Reyna, Darely Y., et al.
Publicado: (2020)

Immunomodulation of tahneeq method in IL-12 and CD8+ T-Lymphocyte, an in-vivo study in neonatal rats
por: Susilorini, et al.
Publicado: (2020)

CD43 Expression Regulated by IL-12 Signaling Is Associated with Survival of CD8 T Cells
por: Lee, Jee-Boong, et al.
Publicado: (2010)

TGF-β Sensitivity Restrains CD8+ T Cell Homeostatic Proliferation by Enforcing Sensitivity to IL-7 and IL-15
por: Johnson, Lisa D. S., et al.
Publicado: (2012)

IL‐12 and IL‐4 activate a CD39‐dependent intrinsic peripheral tolerance mechanism in CD8(+) T cells
por: Noble, Alistair, et al.
Publicado: (2016)

IL-12-conditioning improves retrovirally-mediated transduction efficiency of CD8(+) T cells
por: Andrijauskaite, Kristina, et al.
Publicado: (2015)

IL-12-Induced Immune Suppressive Deficit During CD8+ T-Cell Differentiation
por: Renavikar, Pranav S., et al.
Publicado: (2020)

Acute Neonatal Infections ‘Lock-In’ a Suboptimal CD8+ T Cell Repertoire with Impaired Recall Responses
por: Rudd, Brian D., et al.
Publicado: (2013)

Age-associated alterations in CD8α+ dendritic cells impair CD8 T-cell expansion in response to an intracellular bacterium
por: Li, Gang, et al.
Publicado: (2012)

IL-4 sensitivity shapes the peripheral CD8(+) T cell pool and response to infection
por: Renkema, Kristin R., et al.
Publicado: (2016)

CD161(++)CD8(+) T cells, including the MAIT cell subset, are specifically activated by IL-12+IL-18 in a TCR-independent manner
por: Ussher, James E, et al.
Publicado: (2014)

An extrafollicular pathway for the generation of effector CD8(+) T cells driven by the proinflammatory cytokine, IL-12
por: Shah, Suhagi, et al.
Publicado: (2015)

IL-12 stimulates CTLs to secrete exosomes capable of activating bystander CD8(+) T cells
por: Li, Lei, et al.
Publicado: (2017)

Impaired CD8 T cell memory and CD4 T cell primary responses in IL-7Rα mutant mice
por: Osborne, Lisa C., et al.
Publicado: (2007)

Cholera toxin inhibits IL-12 production and CD8α(+) dendritic cell differentiation by cAMP-mediated inhibition of IRF8 function
por: la Sala, Andrea, et al.
Publicado: (2009)

Cholera toxin inhibits IL-12 production and CD8α(+) dendritic cell differentiation by cAMP-mediated inhibition of IRF8 function
por: la Sala, Andrea, et al.
Publicado: (2009)

Impact of Chronic Rhinosinusitis with Nasal Polyposis on IL-12 and IL-8
por: do Amaral, Janatas Bussador, et al.
Publicado: (2023)

Mitochondrial reactive oxygen is critical for IL-12/IL-18-induced IFN-γ production by CD4(+) T cells and is regulated by Fas/FasL signaling
por: Rackov, Gorjana, et al.
Publicado: (2022)

The Ikaros Transcription Factor Regulates Responsiveness to IL-12 and Expression of IL-2 Receptor Alpha in Mature, Activated CD8 T Cells
por: Clambey, Eric T., et al.
Publicado: (2013)

IL-12 primed CD8+ T-cells possess enhanced persistence and anti-tumor efficacy because of greater IL-7 responsiveness
por: Johnson, C Bryce, et al.
Publicado: (2013)

How the Discovery of the CD4/CD8-p56(lck) Complexes Changed Immunology and Immunotherapy
por: Rudd, Christopher E.
Publicado: (2021)

Carbon source availability drives nutrient utilization in CD8(+) T cells
por: Kaymak, Irem, et al.
Publicado: (2022)

Trained Immunity of IL-12-, IL-15-, and IL-18-Induced CD(3)+CD(56)+ NKT-Like Cells
por: Zhu, Siyu, et al.
Publicado: (2022)

IL-12 and type I interferon prolong the division of activated CD8 T cells by maintaining high-affinity IL-2 signaling in vivo
por: Starbeck-Miller, Gabriel R., et al.
Publicado: (2014)

Defective Transcriptional Programming of Effector CD8 T Cells in Aged Mice Is Cell-Extrinsic and Can Be Corrected by Administration of IL-12 and IL-18
por: Jergović, Mladen, et al.
Publicado: (2019)

What drives a normal relation between T-CD4 and T-CD8?
por: Badura, R, et al.
Publicado: (2010)

Corrigendum: Defective Transcriptional Programming of Effector CD8 T Cells in Aged Mice Is Cell-Extrinsic and Can Be Corrected by Administration of IL-12 and IL-18
por: Jergović, Mladen, et al.
Publicado: (2020)

IL-6 promotes the differentiation of a subset of naive CD8(+) T cells into IL-21–producing B helper CD8(+) T cells
por: Yang, Rui, et al.
Publicado: (2016)

The Third Signal Cytokine IL-12 Rescues the Anti-Viral Function of Exhausted HBV-Specific CD8 T Cells
por: Schurich, Anna, et al.
Publicado: (2013)

Glycogen Synthase Kinase 3 Inactivation Drives T-bet-Mediated Downregulation of Co-receptor PD-1 to Enhance CD8(+) Cytolytic T Cell Responses
por: Taylor, Alison, et al.
Publicado: (2016)

IL-17-Expressing CD4(+) and CD8(+) T Lymphocytes in Human Toxoplasmosis
por: Alves Silva, Jéssica Líver, et al.
Publicado: (2014)

Synergy of IL-21 and IL-15 in regulating CD8(+) T cell expansion and function
por: Zeng, Rong, et al.
Publicado: (2005)

An In-Vitro Study of the Expansion and Transcriptomics of CD(4+) and CD(8+) Naïve and Memory T Cells Stimulated by IL-2, IL-7 and IL-15
por: Hopkins, Brooks, et al.
Publicado: (2022)

NKG2C(+)CD57(+) Natural Killer Cell Expansion Parallels Cytomegalovirus-Specific CD8(+) T Cell Evolution towards Senescence
por: Heath, John, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_rc715u7aif1vvb8l4b2c3famtl