Functional cross-talk between allosteric effects of activating and inhibiting ligands underlies PKM2 regulation

Several enzymes can simultaneously interact with multiple intracellular metabolites, however, how the allosteric effects of distinct ligands are integrated to coordinately control enzymatic activity remains poorly understood. We addressed this question using, as a model system, the glycolytic enzyme...

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Detalles Bibliográficos
Autores principales: Macpherson, Jamie A, Theisen, Alina, Masino, Laura, Fets, Louise, Driscoll, Paul C, Encheva, Vesela, Snijders, Ambrosius P, Martin, Stephen R, Kleinjung, Jens, Barran, Perdita E, Fraternali, Franca, Anastasiou, Dimitrios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Computational and Systems Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6636998/
https://www.ncbi.nlm.nih.gov/pubmed/31264961
http://dx.doi.org/10.7554/eLife.45068

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6636998/
https://www.ncbi.nlm.nih.gov/pubmed/31264961
http://dx.doi.org/10.7554/eLife.45068

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