Uncoupling of p97 ATPase activity has a dominant negative effect on protein extraction

p97 is a highly abundant, homohexameric AAA+ ATPase that performs a variety of essential cellular functions. Characterized as a ubiquitin-selective chaperone, p97 recognizes proteins conjugated to K48-linked polyubiquitin chains and promotes their removal from chromatin and other molecular complexes...

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Detalles Bibliográficos
Autores principales: Rycenga, Halley B., Wolfe, Kelly B., Yeh, Elizabeth S., Long, David T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6637110/
https://www.ncbi.nlm.nih.gov/pubmed/31316150
http://dx.doi.org/10.1038/s41598-019-46949-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6637110/
https://www.ncbi.nlm.nih.gov/pubmed/31316150
http://dx.doi.org/10.1038/s41598-019-46949-4

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