Super-resolution microscopy reveals ultra-low CD19 expression on myeloma cells that triggers elimination by CD19 CAR-T

Immunotherapy with chimeric antigen receptor-engineered T-cells (CAR-T) is under investigation in multiple myeloma. There are reports of myeloma remission after CD19 CAR-T therapy, although CD19 is hardly detectable on myeloma cells by flow cytometry (FC). We apply single molecule-sensitive direct s...

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Detalles Bibliográficos
Autores principales: Nerreter, Thomas, Letschert, Sebastian, Götz, Ralph, Doose, Sören, Danhof, Sophia, Einsele, Hermann, Sauer, Markus, Hudecek, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6637169/
https://www.ncbi.nlm.nih.gov/pubmed/31316055
http://dx.doi.org/10.1038/s41467-019-10948-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6637169/
https://www.ncbi.nlm.nih.gov/pubmed/31316055
http://dx.doi.org/10.1038/s41467-019-10948-w

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