Silencing RORγt in Human CD4(+) T cells with CD30 aptamer-RORγt shRNA Chimera

Targeting specific T cell subtypes and intervening in their function are emerging a critical strategy for treatment of autoimmune diseases. Here we report that an RNA CD30 aptamer was utilized to deliver short hairpin RNA (shRNA) to CD30(+) T cells to target retinoic acid receptor-related orphan rec...

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Detalles Bibliográficos
Autores principales: Shi, Xiaofei, Song, Pingfang, Tao, Shao, Zhang, Xiaowei, Chu, Cong-Qiu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6637186/
https://www.ncbi.nlm.nih.gov/pubmed/31316164
http://dx.doi.org/10.1038/s41598-019-46855-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6637186/
https://www.ncbi.nlm.nih.gov/pubmed/31316164
http://dx.doi.org/10.1038/s41598-019-46855-9

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