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Silencing RORγt in Human CD4(+) T cells with CD30 aptamer-RORγt shRNA Chimera
Targeting specific T cell subtypes and intervening in their function are emerging a critical strategy for treatment of autoimmune diseases. Here we report that an RNA CD30 aptamer was utilized to deliver short hairpin RNA (shRNA) to CD30(+) T cells to target retinoic acid receptor-related orphan rec...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6637186/ https://www.ncbi.nlm.nih.gov/pubmed/31316164 http://dx.doi.org/10.1038/s41598-019-46855-9 |