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Self-DNA at the Epicenter of SLE: Immunogenic Forms, Regulation, and Effects
Self-reactive B cells generated through V(D)J recombination in the bone marrow or through accrual of random mutations in secondary lymphoid tissues are mostly purged or edited to prevent autoimmunity. Yet, 10–20% of all mature naïve B cells in healthy individuals have self-reactive B cell receptors...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Frontiers Media S.A.
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6637313/ https://www.ncbi.nlm.nih.gov/pubmed/31354738 http://dx.doi.org/10.3389/fimmu.2019.01601 |