Facile Formation of β‐thioGlcNAc Linkages to Thiol‐Containing Sugars, Peptides, and Proteins using a Mutant GH20 Hexosaminidase

Thioglycosides are hydrolase‐resistant mimics of O‐linked glycosides that can serve as valuable probes for studying the role of glycosides in biological processes. The development of an efficient, enzyme‐mediated synthesis of thioglycosides, including S‐GlcNAcylated proteins, is reported, using a th...

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Detalles Bibliográficos
Autores principales: Tegl, Gregor, Hanson, John, Chen, Hong‐Ming, Kwan, David H, Santana, Andrés G., Withers, Stephen G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6637381/
https://www.ncbi.nlm.nih.gov/pubmed/30549167
http://dx.doi.org/10.1002/anie.201809928

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6637381/
https://www.ncbi.nlm.nih.gov/pubmed/30549167
http://dx.doi.org/10.1002/anie.201809928

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