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Osteopetrotic induced pluripotent stem cells derived from patients with different disease-associated mutations by non-integrating reprogramming methods

BACKGROUND: Autosomal recessive osteopetrosis is a genetically and phenotypically heterogeneous disease, caused by defects in osteoclast formation and function. The only available treatment is allogeneic stem cell transplantation that has still high morbidity and mortality. The goal of the present s...

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Detalles Bibliográficos
Autores principales: Okur, Fatma Visal, Cevher, İnci, Özdemir, Cansu, Kocaefe, Çetin, Çetinkaya, Duygu Uçkan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6637500/
https://www.ncbi.nlm.nih.gov/pubmed/31315669
http://dx.doi.org/10.1186/s13287-019-1316-8