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Evaluation of simulation models to mimic the distortions introduced into squiggles by nanopore sequencers and segmentation algorithms
Nucleotides ratcheted through the biomolecular pores of nanopore sequencers generate raw picoamperage currents, which are segmented into step-current level signals representing the nucleotide sequence. These ‘squiggles’ are a noisy, distorted representation of the underlying true stepped current lev...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6638935/ https://www.ncbi.nlm.nih.gov/pubmed/31318901 http://dx.doi.org/10.1371/journal.pone.0219495 |