CRLF2 rearrangement in Ph-like acute lymphoblastic leukemia predicts relative glucocorticoid resistance that is overcome with MEK or Akt inhibition

Philadelphia chromosome-like (Ph-like) acute lymphoblastic leukemia (ALL) is a genetically heterogeneous subtype of B-cell ALL characterized by chromosomal rearrangements and mutations that result in aberrant cytokine receptor and kinase signaling. In particular, chromosomal rearrangements resulting...

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Detalles Bibliográficos
Autores principales: Meyer, Lauren K., Delgado-Martin, Cristina, Maude, Shannon L., Shannon, Kevin M., Teachey, David T., Hermiston, Michelle L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6638974/
https://www.ncbi.nlm.nih.gov/pubmed/31318944
http://dx.doi.org/10.1371/journal.pone.0220026

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6638974/
https://www.ncbi.nlm.nih.gov/pubmed/31318944
http://dx.doi.org/10.1371/journal.pone.0220026

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