Activation of IGF1R by DARPP-32 promotes STAT3 signaling in gastric cancer cells

Dopamine and cAMP-regulated phosphoprotein, Mr 32000 (DARPP-32), is frequently overexpressed in earlt stages of gastric cancers. We utilized in vitro assays, 3D gastric gland organoid cultures, mouse models, and human tissue samples to investigate the biological and molecular impact of DARPP-32 on a...

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Detalles Bibliográficos
Autores principales: Zhu, Shoumin, Soutto, Mohammed, Chen, Zheng, Piazuelo, M. Blanca, Washington, M. Kay, Belkhiri, Abbes, Zaika, Alexander, Peng, Dunfa, El-Rifai, Wael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6639157/
https://www.ncbi.nlm.nih.gov/pubmed/31235784
http://dx.doi.org/10.1038/s41388-019-0843-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6639157/
https://www.ncbi.nlm.nih.gov/pubmed/31235784
http://dx.doi.org/10.1038/s41388-019-0843-1

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