Loss of EPAC2 alters dendritic spine morphology and inhibitory synapse density

EPAC2 is a guanine nucleotide exchange factor that regulates GTPase activity of the small GTPase Rap and Ras and is highly enriched at synapses. Activation of EPAC2 has been shown to induce dendritic spine shrinkage and increase spine motility, effects that are necessary for synaptic plasticity. The...

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Detalles Bibliográficos
Autores principales: Jones, Kelly A., Sumiya, Michiko, Woolfrey, Kevin M., Srivastava, Deepak P., Penzes, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academic Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6639166/
https://www.ncbi.nlm.nih.gov/pubmed/31059774
http://dx.doi.org/10.1016/j.mcn.2019.05.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6639166/
https://www.ncbi.nlm.nih.gov/pubmed/31059774
http://dx.doi.org/10.1016/j.mcn.2019.05.001

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