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Selective Kinase Inhibition Shows That Bur1 (Cdk9) Phosphorylates the Rpb1 Linker In Vivo
Cyclin-dependent kinases play multiple roles in RNA polymerase II transcription. Cdk7/Kin28, Cdk9/Bur1, and Cdk12/Ctk1 phosphorylate the polymerase and other factors to drive the dynamic exchange of initiation and elongation complex components over the transcription cycle. We engineered strains of t...
Autores principales: | Chun, Yujin, Joo, Yoo Jin, Suh, Hyunsuk, Batot, Gaëlle, Hill, Christopher P., Formosa, Tim, Buratowski, Stephen |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Microbiology
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6639251/ https://www.ncbi.nlm.nih.gov/pubmed/31085683 http://dx.doi.org/10.1128/MCB.00602-18 |
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