Engineering a Live Attenuated Porcine Epidemic Diarrhea Virus Vaccine Candidate via Inactivation of the Viral 2'-O-Methyltransferase and the Endocytosis Signal of the Spike Protein

Porcine epidemic diarrhea virus (PEDV) causes high mortality in neonatal piglets; however, effective and safe vaccines are still not available. We hypothesized that inactivation of the 2′-O-methyltransferase (2′-O-MTase) activity of nsp16 and the endocytosis signal of the spike protein attenuates PE...

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Detalles Bibliográficos
Autores principales: Hou, Yixuan, Ke, Hanzhong, Kim, Jineui, Yoo, Dongwan, Su, Yunfang, Boley, Patricia, Chepngeno, Juliet, Vlasova, Anastasia N., Saif, Linda J., Wang, Qiuhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2019
Materias:
Vaccines and Antiviral Agents
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6639265/
https://www.ncbi.nlm.nih.gov/pubmed/31118255
http://dx.doi.org/10.1128/JVI.00406-19

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6639265/
https://www.ncbi.nlm.nih.gov/pubmed/31118255
http://dx.doi.org/10.1128/JVI.00406-19

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