Cargando…

Engineering a Live Attenuated Porcine Epidemic Diarrhea Virus Vaccine Candidate via Inactivation of the Viral 2'-O-Methyltransferase and the Endocytosis Signal of the Spike Protein

Porcine epidemic diarrhea virus (PEDV) causes high mortality in neonatal piglets; however, effective and safe vaccines are still not available. We hypothesized that inactivation of the 2′-O-methyltransferase (2′-O-MTase) activity of nsp16 and the endocytosis signal of the spike protein attenuates PE...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hou, Yixuan, Ke, Hanzhong, Kim, Jineui, Yoo, Dongwan, Su, Yunfang, Boley, Patricia, Chepngeno, Juliet, Vlasova, Anastasia N., Saif, Linda J., Wang, Qiuhong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2019
Materias:	Vaccines and Antiviral Agents
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6639265/ https://www.ncbi.nlm.nih.gov/pubmed/31118255 http://dx.doi.org/10.1128/JVI.00406-19

Ejemplares similares

Insight into Vaccine Development for Alphacoronaviruses Based on Structural and Immunological Analyses of Spike Proteins
por: Shi, Yuejun, et al.
Publicado: (2021)

Sertraline Is an Effective SARS-CoV-2 Entry Inhibitor Targeting the Spike Protein
por: Chen, Yuliu, et al.
Publicado: (2022)

Deletion of the SARS-CoV-2 Spike Cytoplasmic Tail Increases Infectivity in Pseudovirus Neutralization Assays
por: Yu, Jingyou, et al.
Publicado: (2021)

SARS-CoV-2 Spike Protein Stabilized in the Closed State Induces Potent Neutralizing Responses
por: Carnell, George W., et al.
Publicado: (2021)

Targeting the Spike Receptor Binding Domain Class V Cryptic Epitope by an Antibody with Pan-Sarbecovirus Activity
por: Jensen, Jaime L., et al.
Publicado: (2023)

Cross-Protection against MERS-CoV by Prime-Boost Vaccination Using Viral Spike DNA and Protein
por: Choi, Jung-ah, et al.
Publicado: (2020)

HIV Protease-Generated Casp8p41, When Bound and Inactivated by Bcl2, Is Degraded by the Proteasome
por: Natesampillai, Sekar, et al.
Publicado: (2018)

Potent Neutralization of SARS-CoV-2 by Hetero-Bivalent Alpaca Nanobodies Targeting the Spike Receptor-Binding Domain
por: Ma, Huan, et al.
Publicado: (2021)

Inactivated H7 Influenza Virus Vaccines Protect Mice despite Inducing Only Low Levels of Neutralizing Antibodies
por: Kamal, Ram P., et al.
Publicado: (2017)

A Methyltransferase-Defective Vesicular Stomatitis Virus-Based SARS-CoV-2 Vaccine Candidate Provides Complete Protection against SARS-CoV-2 Infection in Hamsters
por: Lu, Mijia, et al.
Publicado: (2021)

Structural Study of SARS-CoV-2 Antibodies Identifies a Broad-Spectrum Antibody That Neutralizes the Omicron Variant by Disassembling the Spike Trimer
por: Zhan, Wuqiang, et al.
Publicado: (2022)

Recombinant Infectious Bronchitis Viruses Expressing Chimeric Spike Glycoproteins Induce Partial Protective Immunity against Homologous Challenge despite Limited Replication In Vivo
por: Ellis, Samantha, et al.
Publicado: (2018)

Key Substitutions in the Spike Protein of SARS-CoV-2 Variants Can Predict Resistance to Monoclonal Antibodies, but Other Substitutions Can Modify the Effects
por: Lusvarghi, Sabrina, et al.
Publicado: (2022)

Inactivated SARS-CoV-2 Vaccine Shows Cross-Protection against Bat SARS-Related Coronaviruses in Human ACE2 Transgenic Mice
por: Liu, Mei-Qin, et al.
Publicado: (2022)

Single Immunization with Recombinant ACAM2000 Vaccinia Viruses Expressing the Spike and the Nucleocapsid Proteins Protects Hamsters against SARS-CoV-2-Caused Clinical Disease
por: Deschambault, Yvon, et al.
Publicado: (2022)

COVID-19 Vaccine Candidates Based on Modified Vaccinia Virus Ankara Expressing the SARS-CoV-2 Spike Protein Induce Robust T- and B-Cell Immune Responses and Full Efficacy in Mice
por: García-Arriaza, Juan, et al.
Publicado: (2021)

Comparison of Subgenomic and Total RNA in SARS-CoV-2-Challenged Rhesus Macaques
por: Dagotto, Gabriel, et al.
Publicado: (2021)

Transcriptional Profiling Confirms the Therapeutic Effects of Mast Cell Stabilization in a Dengue Disease Model
por: Morrison, Juliet, et al.
Publicado: (2017)

Association between Hemagglutinin Stem-Reactive Antibodies and Influenza A/H1N1 Virus Infection during the 2009 Pandemic
por: Hoa, Le Nguyen Minh, et al.
Publicado: (2016)

Early Kinetics of the HLA Class I-Associated Peptidome of MVA.HIVconsv-Infected Cells
por: Ternette, Nicola, et al.
Publicado: (2015)

VP2 Exchange and NS3/NS3a Deletion in African Horse Sickness Virus (AHSV) in Development of Disabled Infectious Single Animal Vaccine Candidates for AHSV
por: van de Water, Sandra G. P., et al.
Publicado: (2015)

Molecular Basis of the Divergent Immunogenicity of Two Pediatric Tick-Borne Encephalitis Virus Vaccines
por: Beck, Yvonne, et al.
Publicado: (2016)

A Synthetic Biology Approach for a Vaccine Platform against Known and Newly Emerging Serotypes of Bluetongue Virus
por: Nunes, Sandro Filipe, et al.
Publicado: (2014)

Investigating the Influence of Ribavirin on Human Respiratory Syncytial Virus RNA Synthesis by Using a High-Resolution Transcriptome Sequencing Approach
por: Aljabr, Waleed, et al.
Publicado: (2016)

Protection of Cattle against Rinderpest by Vaccination with Wild-Type but Not Attenuated Strains of Peste des Petits Ruminants Virus
por: Holzer, Barbara, et al.
Publicado: (2016)

Transient CD4(+) T Cell Depletion Results in Delayed Development of Functional Vaccine-Elicited Antibody Responses
por: Provine, Nicholas M., et al.
Publicado: (2016)

A Diverse Panel of Hepatitis C Virus Glycoproteins for Use in Vaccine Research Reveals Extremes of Monoclonal Antibody Neutralization Resistance
por: Urbanowicz, Richard A., et al.
Publicado: (2016)

Chemical Cross-Linking Stabilizes Native-Like HIV-1 Envelope Glycoprotein Trimer Antigens
por: Schiffner, Torben, et al.
Publicado: (2015)

Replicating Single-Cycle Adenovirus Vectors Generate Amplified Influenza Vaccine Responses
por: Crosby, Catherine M., et al.
Publicado: (2017)

Increasing Type 1 Poliovirus Capsid Stability by Thermal Selection
por: Adeyemi, Oluwapelumi O., et al.
Publicado: (2017)

Superior Efficacy of a Human Immunodeficiency Virus Vaccine Combined with Antiretroviral Prevention in Simian-Human Immunodeficiency Virus-Challenged Nonhuman Primates
por: Le Grand, Roger, et al.
Publicado: (2016)

Assembly of Replication-Incompetent African Horse Sickness Virus Particles: Rational Design of Vaccines for All Serotypes
por: Lulla, Valeria, et al.
Publicado: (2016)

Structure-Activity Relationships of the Human Immunodeficiency Virus Type 1 Maturation Inhibitor PF-46396
por: Murgatroyd, Christopher, et al.
Publicado: (2016)

Generation of Long-Lived Bone Marrow Plasma Cells Secreting Antibodies Specific for the HIV-1 gp41 Membrane-Proximal External Region in the Absence of Polyreactivity
por: Donius, Luke R., et al.
Publicado: (2016)

Deep Sequencing of Distinct Preparations of the Live Attenuated Varicella-Zoster Virus Vaccine Reveals a Conserved Core of Attenuating Single-Nucleotide Polymorphisms
por: Depledge, Daniel P., et al.
Publicado: (2016)

Human Monoclonal Antibody 81.39a Effectively Neutralizes Emerging Influenza A Viruses of Group 1 and 2 Hemagglutinins
por: Marjuki, Henju, et al.
Publicado: (2016)

HIV-1 Glycan Density Drives the Persistence of the Mannose Patch within an Infected Individual
por: Coss, Karen P., et al.
Publicado: (2016)

Broadly Neutralizing Antibodies Display Potential for Prevention of HIV-1 Infection of Mucosal Tissue Superior to That of Nonneutralizing Antibodies
por: Cheeseman, Hannah M., et al.
Publicado: (2016)

Immunogenicity in Rabbits of HIV-1 SOSIP Trimers from Clades A, B, and C, Given Individually, Sequentially, or in Combination
por: Torrents de la Peña, Alba, et al.
Publicado: (2018)

HIV-1 Envelope Glycoproteins from Diverse Clades Differentiate Antibody Responses and Durability among Vaccinees
por: Yates, Nicole L., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_n7ohle0q3ubvepr9f46jneki1s