A multi-lock inhibitory mechanism for fine-tuning enzyme activities of the HECT family E3 ligases

HECT E3 ligases control the degradation and functioning of numerous oncogenic/tumor-suppressive factors and signaling proteins, and their activities must be tightly regulated to prevent cancers and other diseases. Here we show that the Nedd4 family HECT E3 WWP1 adopts an autoinhibited state, in whic...

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Detalles Bibliográficos
Autores principales: Wang, Zhen, Liu, Ziheng, Chen, Xing, Li, Jingyu, Yao, Weiyi, Huang, Shijing, Gu, Aihong, Lei, Qun-Ying, Mao, Ying, Wen, Wenyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6639328/
https://www.ncbi.nlm.nih.gov/pubmed/31320636
http://dx.doi.org/10.1038/s41467-019-11224-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6639328/
https://www.ncbi.nlm.nih.gov/pubmed/31320636
http://dx.doi.org/10.1038/s41467-019-11224-7

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