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A multi-lock inhibitory mechanism for fine-tuning enzyme activities of the HECT family E3 ligases
HECT E3 ligases control the degradation and functioning of numerous oncogenic/tumor-suppressive factors and signaling proteins, and their activities must be tightly regulated to prevent cancers and other diseases. Here we show that the Nedd4 family HECT E3 WWP1 adopts an autoinhibited state, in whic...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6639328/ https://www.ncbi.nlm.nih.gov/pubmed/31320636 http://dx.doi.org/10.1038/s41467-019-11224-7 |