Cargando…

The natural compound neobractatin inhibits tumor metastasis by upregulating the RNA-binding-protein MBNL2

Tumor metastasis is the predominant cause of lethality in cancer. We found that Neobractatin (NBT), a natural compound isolated from Garcinia bracteata, could efficiently inhibit breast and lung cancer cells metastasis. However, the mechanisms of NBT inhibiting cancer metastasis remain unclear. Base...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Juan, Zheng, Zhaoqing, Wu, Man, Zhang, Li, Wang, Jing, Fu, Wenwei, Xu, Naihan, Zhao, Zhili, Lao, Yuanzhi, Xu, Hongxi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6639345/ https://www.ncbi.nlm.nih.gov/pubmed/31320607 http://dx.doi.org/10.1038/s41419-019-1789-5

Ejemplares similares

The Natural Compound Neobractatin Induces Cell Cycle Arrest by Regulating E2F1 and Gadd45α
por: Zheng, Zhaoqing, et al.
Publicado: (2019)

RNA-binding Protein MBNL2 regulates Cancer Cell Metastasis through MiR-182-MBNL2-AKT Pathway
por: Lin, Guanglan, et al.
Publicado: (2021)

The natural compound oblongifolin C inhibits autophagic flux and enhances antitumor efficacy of nutrient deprivation
por: Lao, Yuanzhi, et al.
Publicado: (2014)

Screening Active Compounds from Garcinia Species Native to China Reveals Novel Compounds Targeting the STAT/JAK Signaling Pathway
por: Xu, Linfeng, et al.
Publicado: (2015)

Oblongifolin C inhibits metastasis by up-regulating keratin 18 and tubulins
por: Wang, Xiaoyu, et al.
Publicado: (2015)

Gerontoxanthone I and Macluraxanthone Induce Mitophagy and Attenuate Ischemia/Reperfusion Injury
por: Xiang, Qian, et al.
Publicado: (2020)

The Natural Compound Oblongifolin C Exhibits Anticancer Activity by Inhibiting HSPA8 and Cathepsin B In Vitro
por: Han, Li, et al.
Publicado: (2020)

Griffipavixanthone, a dimeric xanthone extracted from edible plants, inhibits tumor metastasis and proliferation via downregulation of the RAF pathway in esophageal cancer
por: Ding, Zhijie, et al.
Publicado: (2015)

MBNL2 Regulates DNA Damage Response via Stabilizing p21
por: Cai, Jin, et al.
Publicado: (2021)

Gambogenic acid inhibits fibroblast growth factor receptor signaling pathway in erlotinib-resistant non-small-cell lung cancer and suppresses patient-derived xenograft growth
por: Xu, Linfeng, et al.
Publicado: (2018)

Alternative splicing mediates the compensatory upregulation of MBNL2 upon MBNL1 loss-of-function
por: Nitschke, Larissa, et al.
Publicado: (2023)

The natural compound Guttiferone F sensitizes prostate cancer to starvation induced apoptosis via calcium and JNK elevation
por: Li, Xin, et al.
Publicado: (2015)

Akt: A Double-Edged Sword in Cell Proliferation and Genome Stability
por: Xu, Naihan, et al.
Publicado: (2012)

Mbnl1 and Mbnl2 regulate brain structural integrity in mice
por: Sta Maria, Naomi S., et al.
Publicado: (2021)

Xanthones from the Leaves of Garcinia cowa Induce Cell Cycle Arrest, Apoptosis, and Autophagy in Cancer Cells
por: Xia, Zhengxiang, et al.
Publicado: (2015)

Identification of MBNL1 and MBNL3 domains required for splicing activation and repression
por: Grammatikakis, Ioannis, et al.
Publicado: (2011)

Natural compound Oblongifolin C confers gemcitabine resistance in pancreatic cancer by downregulating Src/MAPK/ERK pathways
por: Li, Yang, et al.
Publicado: (2018)

Autoregulation of MBNL1 function by exon 1 exclusion from MBNL1 transcript
por: Konieczny, Patryk, et al.
Publicado: (2017)

Mechanistic determinants of MBNL activity
por: Sznajder, Łukasz J., et al.
Publicado: (2016)

MBNL splicing activity depends on RNA binding site structural context
por: Taylor, Katarzyna, et al.
Publicado: (2018)

Mice lacking MBNL1 and MBNL2 exhibit sudden cardiac death and molecular signatures recapitulating myotonic dystrophy
por: Lee, Kuang-Yung, et al.
Publicado: (2022)

MBNL1 regulates isoproterenol‐induced myocardial remodelling in vitro and in vivo
por: Xu, Yao, et al.
Publicado: (2020)

MBNL1 binds GC motifs embedded in pyrimidines to regulate alternative splicing
por: Goers, Emily S., et al.
Publicado: (2010)

MBNL expression in autoregulatory feedback loops
por: Konieczny, Patryk, et al.
Publicado: (2017)

Hypoxia-induced MIR155 is a potent autophagy inducer by targeting multiple players in the MTOR pathway
por: Wan, Gang, et al.
Publicado: (2014)

Lomofungin and dilomofungin: inhibitors of MBNL1-CUG RNA binding with distinct cellular effects
por: Hoskins, Jason W., et al.
Publicado: (2014)

Recent Progress in Understanding the Action of Natural Compounds at Novel Therapeutic Drug Targets for the Treatment of Liver Cancer
por: Zheng, Yannan, et al.
Publicado: (2022)

Fishing for answers: MBNL2 in myotonic dystrophy
Publicado: (2011)

RNA Splicing Is Responsive to MBNL1 Dose
por: Jog, Sonali P., et al.
Publicado: (2012)

CUGBP1 and MBNL1 preferentially bind to 3′ UTRs and facilitate mRNA decay
por: Masuda, Akio, et al.
Publicado: (2012)

Phenylbutazone induces expression of MBNL1 and suppresses formation of MBNL1-CUG RNA foci in a mouse model of myotonic dystrophy
por: Chen, Guiying, et al.
Publicado: (2016)

MBNL proteins and their target RNAs, interaction and splicing regulation
por: Konieczny, Patryk, et al.
Publicado: (2014)

Alternative splicing analysis in human monocytes and macrophages reveals MBNL1 as major regulator
por: Liu, Hongfei, et al.
Publicado: (2018)

(CTG)n repeat-mediated dysregulation of MBNL1 and MBNL2 expression during myogenesis in DM1 occurs already at the myoblast stage
por: André, Laurène M., et al.
Publicado: (2019)

Cognate RNA-Binding Modes by the Alternative-Splicing Regulator MBNL1 Inferred from Molecular Dynamics
por: González, Àlex L., et al.
Publicado: (2022)

LncRNA MBNL1-AS1 Represses Proliferation and Cancer Stem-Like Properties of Breast Cancer through MBNL1-AS1/ZFP36/CENPA Axis
por: Ding, Yu, et al.
Publicado: (2022)

MicroRNA-181a suppresses parkin-mediated mitophagy and sensitizes neuroblastoma cells to mitochondrial uncoupler-induced apoptosis
por: Cheng, Min, et al.
Publicado: (2016)

MBNL1(42) and MBNL1(43) gene isoforms, overexpressed in DM1-patient muscle, encode for nuclear proteins interacting with Src family kinases
por: Botta, A, et al.
Publicado: (2013)

Bioactive natural compounds against human coronaviruses: a review and perspective
por: Xian, Yanfang, et al.
Publicado: (2020)

The four Zn fingers of MBNL1 provide a flexible platform for recognition of its RNA binding elements
por: Cass, Danielle, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_quvrt4ftjro9m2uhg65cf3eu73