Activation of neuronal genes via LINE-1 elements upon global DNA demethylation in human neural progenitors

DNA methylation contributes to the maintenance of genomic integrity in somatic cells, in part through the silencing of transposable elements. In this study, we use CRISPR-Cas9 technology to delete DNMT1, the DNA methyltransferase key for DNA methylation maintenance, in human neural progenitor cells...

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Detalles Bibliográficos
Autores principales: Jönsson, Marie E, Ludvik Brattås, Per, Gustafsson, Charlotte, Petri, Rebecca, Yudovich, David, Pircs, Karolina, Verschuere, Shana, Madsen, Sofia, Hansson, Jenny, Larsson, Jonas, Månsson, Robert, Meissner, Alexander, Jakobsson, Johan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6639357/
https://www.ncbi.nlm.nih.gov/pubmed/31320637
http://dx.doi.org/10.1038/s41467-019-11150-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6639357/
https://www.ncbi.nlm.nih.gov/pubmed/31320637
http://dx.doi.org/10.1038/s41467-019-11150-8

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