Shifting the balance of autophagy and proteasome activation reduces proteotoxic cell death: a novel therapeutic approach for restoring photoreceptor homeostasis

The P23H variant of rhodopsin results in misfolding of the protein, and is a common cause of the blinding disease autosomal dominant retinitis pigmentosa (adRP). We have recently demonstrated that degeneration of photoreceptor cells in retinas of P23H mice is due to the endoplasmic reticulum stress...

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Detalles Bibliográficos
Autores principales: Qiu, Yaoyan, Yao, Jingyu, Jia, Lin, Thompson, Debra A., Zacks, David N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6639359/
https://www.ncbi.nlm.nih.gov/pubmed/31320609
http://dx.doi.org/10.1038/s41419-019-1780-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6639359/
https://www.ncbi.nlm.nih.gov/pubmed/31320609
http://dx.doi.org/10.1038/s41419-019-1780-1

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