Genomic signatures reveal DNA damage response deficiency in colorectal cancer brain metastases

Brain metastases (BM) of colorectal cancer (CRC) are rare but lethal, and an understanding of their genomic landscape is lacking. We conduct an analysis of whole-exome sequencing (WES) and whole-genome sequencing (WGS) data on 19 trios of patient-matched BMs, primary CRC tumors, and adjacent normal...

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Detalles Bibliográficos
Autores principales: Sun, Jing, Wang, Cheng, Zhang, Yi, Xu, Lingyan, Fang, Weijia, Zhu, Yuping, Zheng, Yi, Chen, Xiaofeng, Xie, Xiju, Hu, Xinhua, Hu, Weidong, Zheng, Jingyu, Li, Ping, Yu, Jian, Mei, Zhu, Cai, Xiaomin, Wang, Biao, Hu, Zhibin, Shu, Yongqian, Shen, Hongbing, Gu, Yanhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6639368/
https://www.ncbi.nlm.nih.gov/pubmed/31320627
http://dx.doi.org/10.1038/s41467-019-10987-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6639368/
https://www.ncbi.nlm.nih.gov/pubmed/31320627
http://dx.doi.org/10.1038/s41467-019-10987-3

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