Cargando…

Genomic signatures reveal DNA damage response deficiency in colorectal cancer brain metastases

Brain metastases (BM) of colorectal cancer (CRC) are rare but lethal, and an understanding of their genomic landscape is lacking. We conduct an analysis of whole-exome sequencing (WES) and whole-genome sequencing (WGS) data on 19 trios of patient-matched BMs, primary CRC tumors, and adjacent normal...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sun, Jing, Wang, Cheng, Zhang, Yi, Xu, Lingyan, Fang, Weijia, Zhu, Yuping, Zheng, Yi, Chen, Xiaofeng, Xie, Xiju, Hu, Xinhua, Hu, Weidong, Zheng, Jingyu, Li, Ping, Yu, Jian, Mei, Zhu, Cai, Xiaomin, Wang, Biao, Hu, Zhibin, Shu, Yongqian, Shen, Hongbing, Gu, Yanhong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6639368/ https://www.ncbi.nlm.nih.gov/pubmed/31320627 http://dx.doi.org/10.1038/s41467-019-10987-3

Ejemplares similares

Genome-wide Association Study on Platinum-induced Hepatotoxicity in Non-Small Cell Lung Cancer Patients
por: Cao, Songyu, et al.
Publicado: (2015)

90-gene signature assay for tissue origin diagnosis of brain metastases
por: Zheng, Yulong, et al.
Publicado: (2019)

A Single‐Arm, Phase II Study of Apatinib in Refractory Metastatic Colorectal Cancer
por: Chen, Xiaofeng, et al.
Publicado: (2019)

Chidamide and decitabine can synergistically induce apoptosis of Hodgkin lymphoma cells by up-regulating the expression of PU.1 and KLF4
por: Jiang, Tao, et al.
Publicado: (2017)

Correction: Chidamide and decitabine can synergistically induce apoptosis of Hodgkin lymphoma cells by up-regulating the expression of PU.1 and KLF4
por: Jiang, Tao, et al.
Publicado: (2018)

Liquorrhoea associated with intrapelvic meningocele resection successfully treated by conservative therapy: a case report
por: Xie, Xiju, et al.
Publicado: (2013)

Genetic variants at 8q24 are associated with risk of esophageal squamous cell carcinoma in a Chinese population
por: Dai, Ningbin, et al.
Publicado: (2014)

Identification and validation of a glycolysis-related gene signature for predicting metastasis and survival rate in patients with thyroid cancer
por: Wang, Bo, et al.
Publicado: (2023)

SMAD4 and NF1 mutations as potential biomarkers for poor prognosis to cetuximab-based therapy in Chinese metastatic colorectal cancer patients
por: Mei, Zhu, et al.
Publicado: (2018)

A correlation study of intestinal microflora and first‐episode depression in Chinese patients and healthy volunteers
por: Zheng, Shaojun, et al.
Publicado: (2021)

The Circadian Gene Per1 Plays an Important Role in Radiation-Induced Apoptosis and DNA Damage in Glioma
por: Zhu, Ling, et al.
Publicado: (2019)

hCINAP regulates the DNA-damage response and mediates the resistance of acute myelocytic leukemia cells to therapy
por: Xu, Ruidan, et al.
Publicado: (2019)

Self-Healing, Solvent-Free, Anti-Corrosion Coating Based on Skin-like Polyurethane/Carbon Nanotubes Composites with Real-Time Damage Monitoring
por: Kong, Hui, et al.
Publicado: (2022)

Identification of a Six-Gene SLC Family Signature With Prognostic Value in Patients With Lung Adenocarcinoma
por: Zhu, Jing, et al.
Publicado: (2021)

An individualized gene expression signature for prediction of lung adenocarcinoma metastases
por: Qi, Lishuang, et al.
Publicado: (2017)

A Novel Overall Survival Prediction Signature Based on Comprehensive Research in Prostate Cancer Bone Metastases
por: Hu, Konghe, et al.
Publicado: (2022)

Analysis of Pyroptosis-Related Immune Signatures and Identification of Pyroptosis-Related LncRNA Prognostic Signature in Clear Cell Renal Cell Carcinoma
por: Zhong, Ming, et al.
Publicado: (2022)

Camrelizumab plus gemcitabine and oxaliplatin (GEMOX) in patients with advanced biliary tract cancer: a single-arm, open-label, phase II trial
por: Chen, Xiaofeng, et al.
Publicado: (2020)

Immune-Stromal Score Signature: Novel Prognostic Tool of the Tumor Microenvironment in Lung Adenocarcinoma
por: Qi, Xiaoguang, et al.
Publicado: (2020)

Clinical characteristics of 24 asymptomatic infections with COVID-19 screened among close contacts in Nanjing, China
por: Hu, Zhiliang, et al.
Publicado: (2020)

Genetic susceptibility of cervical cancer
por: Chen, Xiaojun, et al.
Publicado: (2011)

Polygenic score: An anchor holding the whole life course
por: Jin, Guangfu, et al.
Publicado: (2023)

Methylation signature of lymph node metastases in breast cancer patients
por: Barekati, Zeinab, et al.
Publicado: (2012)

Extracellular Vesicles Derived From Talaromyces marneffei Yeasts Mediate Inflammatory Response in Macrophage Cells by Bioactive Protein Components
por: Yang, Biao, et al.
Publicado: (2021)

Outer membrane vesicles-transmitted virulence genes mediate the emergence of new antimicrobial-resistant hypervirulent Klebsiella pneumoniae
por: Hua, Yuneng, et al.
Publicado: (2022)

Pulmonary Function in Patients with Solitary Spinal Metastases: A Hospital-Based Cross-Sectional Study
por: Jia, Fang, et al.
Publicado: (2023)

A Metabolomic Signature of Obesity and Risk of Colorectal Cancer: Two Nested Case–Control Studies
por: Yang, Mingjia, et al.
Publicado: (2023)

Emotional suppression and depressive symptoms in women newly diagnosed with early breast cancer
por: Li, Lingyan, et al.
Publicado: (2015)

Cognitive emotion regulation: characteristics and effect on quality of life in women with breast cancer
por: Li, Lingyan, et al.
Publicado: (2015)

Coping Profiles Differentiate Psychological Adjustment in Chinese Women Newly Diagnosed With Breast Cancer
por: Li, Lingyan, et al.
Publicado: (2016)

Immune Signature of Enhanced Functional Avidity CD8(+) T Cells in vivo Induced by Vaccinia Vectored Vaccine
por: Hu, Zhidong, et al.
Publicado: (2017)

Prevalence and prognostic impact of synchronous distant metastases in patients with hypopharynx squamous cell carcinomas: a SEER-based study
por: Li, Yujiao, et al.
Publicado: (2019)

Association of microRNA polymorphisms with the risk of head and neck squamous cell carcinoma in a Chinese population: a case–control study
por: Miao, Limin, et al.
Publicado: (2016)

A compact VEGF signature associated with distant metastases and poor outcomes
por: Hu, Zhiyuan, et al.
Publicado: (2009)

Study of the shared gene signatures of polyarticular juvenile idiopathic arthritis and autoimmune uveitis
por: Zheng, Jie, et al.
Publicado: (2023)

Construction and Validation of a Combined Ferroptosis and Hypoxia Prognostic Signature for Hepatocellular Carcinoma
por: Wen, Kai, et al.
Publicado: (2021)

RNA sequencing-based longitudinal transcriptomic profiling gives novel insights into the disease mechanism of generalized pustular psoriasis
por: Wang, Lingyan, et al.
Publicado: (2018)

Identification of a 5-gene-based signature to predict prognosis and correlate immunomodulators for rectal cancer
por: Yi, Lin, et al.
Publicado: (2022)

The distribution pattern of pelvic lymph nodal metastases in cervical cancer
por: Xie, Shangdan, et al.
Publicado: (2023)

Role of CXCR3 signaling in response to anti-PD-1 therapy
por: Han, Xiao, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_0ds2okmbvqsp42jir1u8qqu9ih