Structural mechanism of synergistic activation of Aurora kinase B/C by phosphorylated INCENP

Aurora kinases B and C (AURKB/AURKC) are activated by binding to the C-terminal domain of INCENP. Full activation requires phosphorylation of two serine residues of INCENP that are conserved through evolution, although the mechanism of this activation has not been explained. Here we present crystal...

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Detalles Bibliográficos
Autores principales: Abdul Azeez, Kamal R., Chatterjee, Sneha, Yu, Channing, Golub, Todd R., Sobott, Frank, Elkins, Jonathan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6639382/
https://www.ncbi.nlm.nih.gov/pubmed/31320618
http://dx.doi.org/10.1038/s41467-019-11085-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6639382/
https://www.ncbi.nlm.nih.gov/pubmed/31320618
http://dx.doi.org/10.1038/s41467-019-11085-0

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