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Structural mechanism of synergistic activation of Aurora kinase B/C by phosphorylated INCENP
Aurora kinases B and C (AURKB/AURKC) are activated by binding to the C-terminal domain of INCENP. Full activation requires phosphorylation of two serine residues of INCENP that are conserved through evolution, although the mechanism of this activation has not been explained. Here we present crystal...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6639382/ https://www.ncbi.nlm.nih.gov/pubmed/31320618 http://dx.doi.org/10.1038/s41467-019-11085-0 |