Grb2 binds to PTEN and regulates its nuclear translocation to maintain the genomic stability in DNA damage response

Growth factor receptor bound protein 2 (Grb2) is an adaptor protein critical for signal transduction and endocytosis, but its role in DNA damage response (DDR) remains unknown. Here, we report that either knockdown of Grb2 or overexpression of the mutated Grb2 promotes micronuclei formation in respo...

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Detalles Bibliográficos
Autores principales: Hou, Bolin, Xu, Shanshan, Xu, Yang, Gao, Quan, Zhang, Caining, Liu, Ling, Yang, Huaiyi, Jiang, Xuejun, Che, Yongsheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6639399/
https://www.ncbi.nlm.nih.gov/pubmed/31320611
http://dx.doi.org/10.1038/s41419-019-1762-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6639399/
https://www.ncbi.nlm.nih.gov/pubmed/31320611
http://dx.doi.org/10.1038/s41419-019-1762-3

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